50 Cent joins Em on the amphitheatre and arena tour for all but the first two dates, which will feature Ludicris in his place.

This is the first U.S. tour that pairs Eminem with partner in rhyme 50 Cent. This will be afamily affair for Fitty, with G-Unit joining him on the road.

The chart dominating rapper 50 Cent is working on his film debut, and due to the movie’s production schedule he will be unable to appear at the Indianapolis and Columbus dates.

King of crunk Lil Jon along with his East Side Boyz will start off the night for the entire tour.

“We’ve been waiting for the right moment to go on tour, and it all finally came together,” said Eminem. “We wanted to put together the best lineup we could … I’m always trying to top the last tour whenever I go out. I think we’re really doing it this time.”

Eminem’s entire Shady Records family will be on the road with him for the five and a half week run. Besides hearing songs from Encore performed live for the first time, concertgoers will see performances from D-12, Obie Trice, and the newest addition to the family, Atlanta’s Stat Quo. Mixtape king Green Lantern will, as usual, be behind the turntables.

“Whenever I get together with Em you know it’s going to be hot,” 50 Cent said of the tour. “You better put in for that time off from the job now, before somebody else beats you to it. Or quit your job so you can see every show.”

Those who can’t quit their jobs can tune in to Sirius Satellite Radio’s Shade 45 channel for tour coverage, exclusive live performances, and backstage interviews.