Houston will be the queen of talk’s first guest as she launches season 24 of her juggernaut of a show on Sept. 14.

Winfrey’s Web site calls the singer’s appearance “the most anticipated music interview of the decade.”

Houston’s stop by Oprah’s couch is the first time the troubled singer has done a major TV interview since 2002, when she chatted with ABC’s Diane Sawyer about her ongoing struggle with substance abuse.

Thursday, August 20
T.J. Miller, George Wallace, Natasha Leggero – “Chelsea Lately”
Gary Mule Deer – “Late Show with David Letterman”
Grizzly Bear – “Late Night with Jimmy Fallon” – rerun
Doug Benson – “Jimmy Kimmel Live!” – rerun
Chairlift – “Late Late Show with Craig Ferguson” – rerun
Operation Aloha – “Last Call with Carson Daly” – rerun

Friday, August 21
Carol Leifer – “The View” – rerun
Brad Wollack, Tony Rock, Sarah Colonna – “Chelsea Lately” – rerun
Patton Oswalt – “Late Show with David Letterman”
The Dead Weather – “The Tonight Show with Conan O’Brien” – rerun
Jack’s Mannequin – “Jimmy Kimmel Live!” – rerun
No Doubt, Friendly Fires – “Last Call with Carson Daly” – rerun

Saturday, August 22
Nick Lowe, The Swell Season – “Austin City Limits” – rerun
Adele – “Saturday Night Live” – rerun