Seinfeld will join previously announced musical guests Jay-Z, Rihanna and Kanye West. The new weeknight prime-time series debuts Sept. 14.

Leno stepped down in May as host of the “Tonight Show” after 17 years.

Seinfeld, who starred in his own hit NBC comedy, will be returning to the network early next year with “The Marriage Ref,” a reality series that he’ll produce.