Set for Jan. 20 at The Colosseum at Caesars Palace, the event is presented by Caesars Entertainment and AEG Live.

Dion has a personal connection to the benefit. In 1993 the singer lost her niece Karine to the disease. Dion, who has worked with Cystic Fibrosis Canada since she was a teenager, is currently the organization’s celebrity patron.

“I’m honored to be able to team up with the Cystic Fibrosis Foundation and my partners at Caesars Entertainment and AEG Live to raise funds and awareness on Jan. 20th for this very worty cause,” Dion said. “We’re making dramatic progress in treating this terrible disease, and I truly hope that one day soon, CF will stand for ‘cure found.’”

Directed by Grammy Awards producer Ken Ehrlich, the show will feature a 31-piece orchestra backing Dion.

Tickets range from $55-$250 with VIP packages available. Click here for more information.